Unlocking the promise of Unnatural Amino Acids
AsisChem is dedicated to delivering New Products and Advancements in the field of medicinal chemistry. For example, we have recently focused our efforts on developing families of unnatural amino acids, including L‑ANAP derivatives - fluorescent amino acids; Bipyridylalanine (BPY, BpyAla) - metal-binding amino acids and others.
L-ANAP (L)-3-(6-acetylnaphtalen-2-ylamino)-2-aminopropanonic acid is a small organic fluorophore that can be genetically encoded into the primary protein using a tRNA/synthetase pair that is readily available from addgene [1-4]. Our Methyl Ester derivative (L-ANAP-ME) works flawlessly with the tRNA/synthetase kit, making fluorescent Unnatural amino acid assays available to the wider research community for the first time.