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Removing Plaque from Alzheimer Brains

January 15, 2010 06:10 by asischemadmin

January 2010 Newsletter  

Greetings!

I hope everyone had a joyous holiday season!  Though some of you might have had a fantastic 2009 I am betting the majority of us are looking forward to a more prosperous 2010.  To start us of on the right foot we are co-hosting a workshop in the Boston area focused on obtaining funding for drug discovery projects.  If you are in the area we would love to see you.  If not, you can always contact Mel Bellott for information about:

  • The value of early ADMET screening of candidate compounds
  • How medicinal chemistry efforts contribute to your program's success
  • Developing a program framework for drug discovery
  • Lead compound strategy

 

As always enjoy!


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Chemistry (The Dork Song) (click for video)




"Nano Cocktail" to Target and Kill Tumors A team of researchers in California and Massachusetts has developed a "cocktail" of different nanometer-sized particles that work in concert within the bloodstream to locate, adhere to and kill cancerous tumors. Read More

Nanoparticles Bypass Mucus Barrier, May Deliver Drugs  Johns Hopkins University researchers have created biodegradable nanosized particles that can easily slip through the body's sticky and viscous mucus secretions to deliver a sustained-release medication cargo. The researchers say that these nanoparticles, which degrade over time into harmless components, could one day carry life-saving drugs to patients suffering from dozens of health conditions, including diseases of the eye, lung, gut or female reproductive tract. Read More

Scientists Remove Plaque from Brains with Alzheimer's Disease A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques-considered a hallmark of the disease-from patients' brains. This discovery, is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove plaques instead of causing them or making them worse. The research was performed in a model of Alzheimer's disease established in mice. Read More 


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I know there are projects that need custom synthesis, medicinal chemistry or chemical consulting. Why wait any longer submit an inquiry!

Sincerely,

 

Bryan Roland,

Director - Project Management

Bryan.Roland@asischem.com


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Brain Proteins Suggest Possible Way to Fight Alzheimer's

October 8, 2009 23:23 by asischemadmin

October 2009 Newsletter  

Greetings!

Happy Mole Day! I suppose have a scary Halloween as well. I don't know what is going on for Halloween, but I am definitely celebrating Mole day with Chicken Mole from my favorite Mexican restaurant (an old tradition from my time in Tucson, Az). I hope whichever holiday you choose to participate in you enjoy it as much as I will. Anyway, there were so many interesting research articles to choose from this month I just chose a few I thought you might like. Enjoy.

The Mole Song



Brain Proteins Suggest Possible Way to Fight Alzheimer's

DALLAS - Oct. 6, 2009 - The action of asmall protein that is a major villain in Alzheimer's disease can becounterbalanced with another brain protein, researchers at UT Southwestern Medical Center have found in an animal study.

The findings, available online in the journal Proceedings of the National Academy of Sciences, suggest a promising new tactic against the devastating illness, the researchers said. Read More

How Soy Reduces Diabetes Risk

AMHERST, Mass. -Nutrition scientists led by Young-Cheul Kim atthe University of Massachusetts Amherst have identified the molecularpathway that allows foods rich in soy bioactive compounds calledisoflavones to lower diabetes and heart disease risk. Eating soy foodshas been shown to lower cholesterol, decrease blood glucose levels andimprove glucose tolerance in people with diabetes. Read More

A Step Toward Better Brain Implants Using Conducting Polymer Nanotubes

ANN ARBOR, Mich.-Brain implants that can more clearly record signalsfrom surrounding neurons in rats have been created at the University ofMichigan. The findings could eventually lead to more effectivetreatment of neurological disorders such as Parkinson's disease andparalysis. Neural electrodes must work for time periods ranging from hours toyears. When the electrodes are implanted, the brain first reacts to theacute injury with an inflammatory response. Then the brain settles intoa wound-healing, or chronic, response. Read More

Please send us some questions, inquiries, challenges or anything else chemistry related. Put our expert chemists to the test by submitting an inquiry!

Sincerely,
Bryan Roland, Director - Project Management
Bryan.Roland@asischem.com

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